As man struggled to rebuild his civilization, tension mounted between the growing Mutant Human population and the Normal Humans controlling the World-Wide Second Republic. The Second Republic treated Mutants with few noticable changes as "Acceptable", yet second-class citizens, but those with many noticeable changes were branded "Mutazoid" and treated far worse.

Meanwhile, the Outlands overgrew rapidly as man retreated to his cities. Then, almost overnight, man was no longer alone among sentients. Species of sentient life awakened from the Animal and Plant kingdoms. Some were spawned by rampant perMutations of the original nano-Mutazoid plague in the wild, and others were purposely genetically engineered in secret laboratories. These new forms of the virus were much less virulent than the original form that had infected the Human race. In most cases, 20% of the population was affected and 80% remained normal. Very few died. Some new creatures were sentient and some were not. These new races were of various forms depending on the strain that infected their parents.

Then in 2109, a radical group of death-worshipping extremists launched several nuclear strikes. The Second Republic employed long forgotten anti-missile defense systems, and the missiles fail to strike any significant targets. They did, however, cause substantial ecological damage, and the unexpected strike was the catalyst that launched the Mutazoid Rebellion. The rebellion lasted for 8 bloody years, ending in the cease-fire of 2117. Rumored to be funded by the off world colonies, the rebels had access to advanced weaponry and armaments. These were quickly duplicated in the factories of the Second Republic, causing a brief technological boom. The rebels were also supplied with high quality counterfeit money to attack the Second Republic economically, and this furthered speculation that the rebels were receiving off-world help.

The rebellion practically destroyed the Second Republic. Much as it was before the Republic took power in 2050, feudal warlords fill the void with various titles and dubious authority. It is now 2123.